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TMBpro Overview

TMBpro is a suite of specialized predictors for predicting secondary structure, beta-contacts, and tertiary structure of Transmembrane Beta-Barrel (TMB) proteins. TMB proteins are embedded in the outer membranes of mitochondria, Gram-negative bacteria and chloroplasts. These proteins perform critical functions, including active ion-transport and passive nutrient intake. Therefore, there is a need for accurate prediction of secondary and tertiary structure of TMB proteins. Traditional homology modeling methods, however, fail on most TMB proteins since very few non-homologous TMB structures have been determined. Yet, because TMB structures conform to specific construction rules that restrict the conformational space drastically, it is possible for alignment free methods, such as TMBpro, to be applied successfully.

TMBpro References



Contact TMBpro Administrator: arandall@ics.uci.edu

Institute for Genomics and Bioinformatics
School of Information & Computer Science
University of California Irvine